Clinical trials using adult stem cells to treat MS (video)
Bill White, 46, of North Olmsted, is a regular at the Power House Gym in North Olmsted, despite being diagnosed with multiple sclerosis in 2007. White is the first patient enrolled in a new joint clinical trial of the Cleveland Clinic, University Hospitals and the Case Western Reserve University School of Medicine. The clinical trial is testing to see whether White's own stem cells can be used to help treat MS.CLEVELAND, Ohio -- Each year in the United States, about 10,000 people are diagnosed with multiple sclerosis. A long-term treatment that not only relieves symptoms but also repairs the damage caused by the disease has eluded researchers.
Now, the Cleveland Clinic, University Hospitals Seidman Cancer Center and Case Western Reserve University are collaborating on a one-of-a-kind clinical trial in the United States, designed to treat, or even reverse, the debilitating effects of multiple sclerosis by using a patient's own adult stem cells.
Mesenchymal stem cells, or MSCs, are found in the bone marrow. More than 150 other clinical trials in the United States and around the world are currently testing MSCs' ability to encourage tissue repair as a way to treat a variety of other conditions such as osteoarthritis, diabetes, emphysema and stroke. Stem cell therapy is already used to treat leukemia, lymphoma and certain blood disorders.
In the Phase One trial here, a patient's MSCs are harvested at UH, carefully cultivated in a special laboratory at CWRU and then injected intravenously back into the patient at the Clinic.
Since June, two patients have undergone the entire process. A third is scheduled to receive an infusion of MSCs on Monday. A total of 24 patients with relapsing or progressively worse MS who have moderate to severe disability will take part in the study over the next two to three years.
The primary aim is to test the feasibility and safety of using the body's own stem cells to treat MS. But researchers also are looking closely for any preliminary evidence that the transplanted cells could moderate the over-active immune system, possibly stopping or even repairing tissue damage.
Case Studies In Human Nervous Sytem - News
The study of the nervous system of the brain and body – the field of neuroscience – is increasingly going mainstream. More and more, what's on the minds of an increasing number of people is … their own mind. Among the most amazing discovery is
Multiple sclerosis is an autoimmune disease that affects the brain and central nervous system. In people with MS, the immune system abnormally attacks the central nervous system, causing damage to the nerve cells and their protective myelin sheath.
"This study is not up to the usual quality seen in the Journal of the National Cancer Institute, and it seems that it was rushed into print," she said. The study in question, known as CEFALO, was an international case–control study that examined the
University of Otago, Christchurch, researchers were involved in the study and more than 1000 New Zealanders contributed samples. MS is a disorder of the central nervous system which includes the brain, spinal cord and optic nerves.
Do dolphins have language with the scope and breadth to converse about anything like we can with human language, or is it more basic? Justin Gregg would argue the latter case. "Essentially they do behave in complex and interesting ways, but there are
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